Treatment Options for Hypercortisolism

The goal of treatment is to reduce the negative effects of excess cortisol activity. This often noticeably improves symptoms associated with hypercortisolism.

Treatment options include:

Surgery—to remove the tumor

Radiation—to reduce the tumor size

Medication—to help manage signs and symptoms of the disease

Learn About a Medication Called Korlym®

It is important to remember that high cortisol activity physically changes the body, and reversing these changes may take time.

 


References:

  1. Lonser RR, Nieman L, Oldfield EH. Cushing’s disease: pathobiology, diagnosis, and management. J Neurosurg. 2017;126:404-417.
  2. Rizk A, Honegger J, Milian M, Psaras T. Treatment options in Cushing’s Disease. Clin Med Insights: Oncol. 2012;6:75-84.
  3. Fleseriu M, Biller BMK, Findling JW, Molitch ME, Schteingart DE, Gross C; for SEISMIC Study Investigators. Mifepristone, a glucocorticoid antagonist, produces clinical and metabolic benefits in patients with Cushing’s syndrome. J Endocrinol Metab. 2012;97(6):2039-2049.
  4. The Pituitary Society. Cushing’s syndrome & disease—after treatment. http://www.pituitarysociety.org/patient-education/pituitary-disorders/cushings/after-treatment-of-cushings-disease-and-cushings-syndrome. Accessed May 12, 2018.

Important Safety Information and Indications IMPORTANT SAFETY INFORMATION ABOUT KORLYM, INCLUDING IMPORTANT WARNING ON LOSS OF PREGNANCY.

MOST IMPORTANT INFORMATION ABOUT KORLYM® (MIFEPRISTONE) 300 mg TABLETS

Korlym should never be taken by women who are pregnant or who might become pregnant. Taking Korlym during pregnancy will result in the loss of a pregnancy. A pregnancy test is required before starting Korlym or if treatment is interrupted for more than 14 days. Talk with your doctor about how to prevent pregnancy.

Tell your doctor and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Korlym and certain other medications may affect each other or may cause side effects.

Do not take Korlym if:

  • you are taking certain medications for high cholesterol, such as simvastatin (Zocor®) or lovastatin (Mevacor®), as Korlym may cause a dangerous increase in the level of these medications in the blood
  • you take corticosteroid medications like prednisone to treat a serious medical condition
  • you have experienced unexplained vaginal bleeding, changes in the cells lining your uterus (endometrial hyperplasia), or cancer of the lining of your uterus (endometrial cancer)

What Are the Possible Side Effects of Korlym?

Patients taking Korlym should be monitored for side effects. Potential serious side effects include signs of adrenal insufficiency, low potassium levels, changes to the lining of the uterus, vaginal bleeding, and problems with the electrical system of the heart.

The most common side effects of Korlym include nausea, fatigue, headache, low potassium in the blood, pain in arms and legs (arthralgia), vomiting, swelling of arms and legs (peripheral edema), high blood pressure, dizziness, decreased appetite, and thickening of the lining of the uterus (endometrial hypertrophy).

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of Korlym. For more information, ask your doctor or pharmacist. For medical advice about side effects, call your doctor.

Nursing mothers should discontinue Korlym or discontinue breastfeeding — talk with your doctor to determine if you should take Korlym.

Complete warnings and other important safety information are available in the accompanying full Prescribing Information and Medication Guide.

What Is Korlym?

Korlym is a prescription medicine used to treat high blood sugar (hyperglycemia) caused by high cortisol levels in the blood (hypercortisolism) in adults with endogenous Cushing’s syndrome who have type 2 diabetes mellitus or glucose intolerance and who cannot have surgery or for whom surgery has failed. Korlym is not for people who have type 2 diabetes mellitus not caused by Cushing’s syndrome.