Korlym helps decrease symptoms of excess cortisol activity, such as high blood sugar.
Korlym® (mifepristone) is a cortisol receptor blocker indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing’s syndrome who have type 2 diabetes mellitus or glucose intolerance and have failed surgery or are not candidates for surgery.
Important Limitations of Use
Do not use for the treatment of type 2 diabetes mellitus unrelated to endogenous Cushing’s syndrome.
Whether you are seeking more information about Cushing syndrome (also called hypercortisolism), or just need someone to talk to about what you are going through, a Patient Advocate is available to:
Korlym should never be taken by women who are pregnant or who might become pregnant. Taking Korlym during pregnancy will result in the loss of a pregnancy. A pregnancy test is required before starting Korlym or if treatment is interrupted for more than 14 days. Talk with your doctor about how to prevent pregnancy.
Tell your doctor and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Korlym and certain other medicines, may affect each other or may cause side effects.
Do not take Korlym if:
Patients taking Korlym should be monitored for side effects. Potential serious side effects include signs of adrenal insufficiency, low potassium levels, changes to the lining of the uterus, vaginal bleeding, and problems with the electrical system of the heart.
The most common side effects of Korlym include nausea, fatigue, headache, low potassium in the blood, pain in arms and legs (arthralgia), vomiting, swelling of arms and legs (peripheral edema), high blood pressure, dizziness, decreased appetite, and thickening of the lining of the uterus (endometrial hypertrophy).
Tell your doctor if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of Korlym. For more information, ask your doctor or pharmacist. For medical advice about side effects, call your doctor.
Before taking Korlym, talk to your doctor if you are breastfeeding or plan to breastfeed.
Korlym is a prescription medicine used to treat high blood sugar (hyperglycemia) caused by high cortisol levels in the blood (hypercortisolism) in adults with endogenous Cushing syndrome who have type 2 diabetes mellitus or glucose intolerance and who cannot have surgery or for whom surgery has failed. Korlym is not for people who have type 2 diabetes mellitus not caused by Cushing syndrome.